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Context. Flares in radio-loud active galactic nuclei are thought to be associated with the injection of fresh plasma into the compact jet base. Such flares are usually strongest and appear earlier at shorter radio wavelengths. Hence, very long baseline interferometry (VLBI) at millimeter(mm)-wavelengths is the best-suited technique for studying the earliest structural changes of compact jets associated with emission flares. Aims. We study the morphological changes of the parsec-scale jet in the nearby (z = 0.049) γ-ray bright radio galaxy 3C 111 following a flare that developed into a major radio outburst in 2007. Methods. We analyse three successive observations of 3C 111 at 86 GHz with the Global mm-VLBI Array (GMVA) between 2007 and 2008 which yield a very high angular resolution of ∼45 μas. In addition, we make use of single-dish radio flux density measurements from the F-GAMMA and POLAMI programmes, archival single-dish and VLBI data. Results. We resolve the flare into multiple plasma components with a distinct morphology resembling a bend in an otherwise remarkably straight jet. The flare-associated features move with apparent velocities of ∼4.0c to ∼4.5c and can be traced also at lower frequencies in later epochs. Near the base of the jet, we find two bright features with high brightness temperatures up to ∼1011 K, which we associate with the core and a stationary feature in the jet. Conclusions. The flare led to multiple new jet components indicative of a dynamic modulation during the ejection. We interpret the bend-like feature as a direct result of the outburst which makes it possible to trace the transverse structure of the jet. In this scenario, the components follow different paths in the jet stream consistent with expectations for a spine-sheath structure, which is not seen during intermediate levels of activity. The possibility of coordinated multiwavelength observations during a future bright radio flare in 3C 111 makes this source an excellent target for probing the radio-γ-ray connection. © ESO 2020. ; We would like to thank the anonymous referee for helpful comments that improved the manuscript. We would like to thank the internal MPIfR referee N. MacDonald for insightful comments that helped improve the manuscript. RS gratefully acknowledge support from the European Research Council under the European Union's Seventh Framework Programme (FP/2007-2013)/ERC Advanced Grant RADIOLIFE-320745 and support by Deutsche Forschungsgemeinschaft grant WI 1860/10-1. MP acknowledges financial support from the Spanish Ministry of Science through Grants PID2019-105510GB-C31, PID2019-107427GB-C33 and AYA2016-77237-C3-3-P, and from the Generalitat Valenciana through grant PROMETEU/2019/071. I.A. acknowledges support by a Ramon y Cajal grant (RYC-2013-14511) of the "Ministerio de Ciencia e Innovacion (MICINN)" of Spain. He also acknowledges financial support from MCINN through the "Center of Excellence Severo Ochoa" award for the Instituto de Astrofisica de Andalucia-CSIC (SEV-2017-0709). Acquisition and reduction of the POLAMI data was supported in part by MICINN through grant AYA2016-80889-P. IRAM is supported by INSU/CNRS (France), MPG (Germany) and IGN (Spain). This research has made use of data obtained with the Global Millimeter VLBI Array (GMVA), which consists of telescopes operated by the MPIfR, IRAM, Onsala, Metsahovi, Yebes, the Korean VLBI Network, the Green Bank Observatory and the Very Long Baseline Array (VLBA). The VLBA is a facility of the National Science Foundation operated under cooperative agreement by Associated Universities, Inc. The data were correlated at the correlator of the MPIfR in Bonn, Germany. This study makes use of 43 GHz VLBA data from the Boston University gamma-ray blazar monitoring program (http://www.bu.edu/blazars/VLBAproject.html), funded by NASA through the Fermi Guest Investigator Program. This research has made use of data from the MOJAVE database that is maintained by the MOJAVE team (Lister et al. 2009). The Very Long Baseline Array (VLBA) is an instrument of the National Radio Astronomy Observatory (NRAO). NRAO is a facility of the National Science Foundation, operated by Associated Universities Inc. This research made use of the Interactive Spectral Interpretation System (ISIS) (Houck & Denicola 2000) and a collection of ISIS scripts provided by the Dr. Karl Remeis observatory, Bamberg, Germany at http://www.sternwarte.uni-erlangen.de/isis/. This research made use of the NASA/IPAC Extragalactic Database (NED), which is operated by the Jet Propulsion Laboratory, California Institute of Technology, under contract with the National Aeronautics and Space Administration and of the VizieR catalogue access tool, CDS, Strasbourg, France. ; Peer reviewed

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) ; European Union Grant LIFECYCLE ; Norwegian Research Council BIOTEK2021 program ; project SALMOSTERILE ; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) ; Processo FAPESP: 12/00423-6 ; Processo FAPESP: 14/07620-7 ; European Union Grant LIFECYCLE: FP7-222719 ; project SALMOSTERILE: 221648 ; CNPq: 201488/2014-0 ; Fsh-mediated regulation of zebrafish spermatogenesis includes modulating the expression of testicular growth factors. Here, we study if and how two Sertoli cell-derived Fsh-responsive growth factors, anti-Mullerian hormone (Amh; inhibiting steroidogenesis and germ cell differentiation) and insulin-like growth factor 3 (Igf3; stimulating germ cell differentiation), cooperate in regulating spermatogonial development. In dose response and time course experiments with primary testis tissue cultures, Fsh up regulated igf3 transcript levels and down-regulated amh transcript levels; igf3 transcript levels were more rapidly up-regulated and responded to lower Fsh concentrations than were required to decrease amh mRNA levels. Quantification of immunoreactive Amh and Igf3 on testis sections showed that Fsh increased slightly Igf3 staining but decreased clearly Amh staining. Studying the direct interaction of the two growth factors showed that Amh compromised Igf3-stimulated proliferation of type A (both undifferentiated [A(und)] and differentiating [A(diff)]) spermatogonia. Also the proliferation of those Sertoli cells associated with Aund spermatogonia was reduced by Amh. To gain more insight into how Amh inhibits germ cell development, we examined Amh-induced changes in testicular gene expression by RNA sequencing. The majority (69%) of the differentially expressed genes was down-regulated by Amh, including several stimulators of spermatogenesis, such as igf3 and steroidogenesis-related genes. At the same time, Amh increased the expression of inhibitory signals, such as inha and id3, or facilitated prostaglandin E-2 (PGE(2)) signaling. Evaluating one of the potentially inhibitory signals, we indeed found in tissue culture experiments that PGE(2) promoted the accumulation of Aund at the expense of Ada and B spermatogonia. Our data suggest that an important aspect of Fsh bioactivity in stimulating spermatogenesis is implemented by restricting the different inhibitory effects of Amh and by counterbalancing them with stimulatory signals, such as Igf3. (C) 2017 Elsevier B.V. All rights reserved.

Understanding the spatiotemporal patterns of legacy organochlorines (OCs) is often difficult because monitoring practices differ among studies, fragmented study periods, and unaccounted confounding by ecological variables. We therefore reconstructed long-term (1939–2015) and large-scale (West Greenland, Norway, and central Sweden) trends of major legacy OCs using white-tailed eagle ( Haliaeetus albicilla ) body feathers, to understand the exposure dynamics in regions with different contamination sources and concentrations, as well as the effectiveness of legislations. We included dietary proxies ( δ 13 C and δ 15 N) in temporal trend models to control for potential dietary plasticity. Consistent with the hypothesised high local pollution sources, levels of polychlorinated biphenyls (PCBs), dichlorodiphenyltrichloroethanes (DDTs) and hexachlorocyclohexanes (HCHs) in the Swedish subpopulation exceeded those in the other subpopulations. In contrast, chlordanes (CHLs) and hexachlorobenzene (HCB) showed higher concentrations in Greenland, suggesting the importance of long-range transport. The models showed significantly decreasing trends for all OCs in Sweden in 1968–2011 except for CHLs, which only decreased since the 1980s. Nevertheless, median concentrations of DDTs and PCBs remained elevated in the Swedish subpopulation throughout the 1970s, suggesting that the decreases only commenced after the implementation of regulations during the 1970s. We observed significant trends of increasing concentrations of PCBs, CHLs and HCB in Norway from the 1930s to the 1970s/1980s and decreasing concentrations thereafter. All OC concentrations, except those of PCBs were generally significantly decreasing in the Greenland subpopulation in 1985-2013. All three subpopulations showed generally increasing proportions of the more persistent compounds (CB 153, p.p ′-DDE and β -HCH) and decreasing proportions of the less persistent ones (CB 52, p.p ′-DDT, α - and γ -HCH). Declining trends of OC concentrations may imply the decreasing influence of legacy OCs in these subpopulations. Finally, our results demonstrate the usefulness of archived museum feathers in retrospective monitoring of spatiotemporal trends of legacy OCs using birds of prey as sentinels.

Context. While studies of large samples of jets of active galactic nuclei (AGN) are important in order to establish a global picture, dedicated single-source studies are an invaluable tool for probing crucial processes within jets on parsec scales. These processes involve in particular the formation and geometry of the jet magnetic field as well as the flow itself. Aims. We aim to better understand the dynamics within relativistic magneto-hydrodynamical flows in the extreme environment and close vicinity of supermassive black holes. Methods. We analyze the peculiar radio galaxy 3C 111, for which long-Term polarimetric observations are available. We make use of the high spatial resolution of the VLBA network and the MOJAVE monitoring program, which provides high data quality also for single sources and allows us to study jet dynamics on parsec scales in full polarization with an evenly sampled time-domain. While electric vectors can probe the underlying magnetic field, other properties of the jet such as the variable (polarized) flux density, feature size, and brightness temperature, can give valuable insights into the flow itself. We complement the VLBA data with data from the IRAM 30-m Telescope as well as the SMA. Results. We observe a complex evolution of the polarized jet. The electric vector position angles (EVPAs) of features traveling down the jet perform a large rotation of &180across a distance of about 20 pc. As opposed to this smooth swing, the EVPAs are strongly variable within the first parsecs of the jet.We find an overall tendency towards transverse EVPAs across the jet with a local anomaly of aligned vectors in between. The polarized flux density increases rapidly at that distance and eventually saturates towards the outermost observable regions. The transverse extent of the flow suddenly decreases simultaneously to a jump in brightness temperature around where we observe the EVPAs to turn into alignment with the jet flow. Also the gradient of the feature size and particle density with distance steepens significantly at that region. Conclusions. We interpret the propagating polarized features as shocks and the observed local anomalies as the interaction of these shocks with a localized recollimation shock of the underlying flow. Together with a sheared magnetic field, this shock-shock interaction can explain the large rotation of the EVPA. The superimposed variability of the EVPAs close to the core is likely related to a clumpy Faraday screen, which also contributes significantly to the observed EVPA rotation in that region.© ESO 2018. ; T.B. is grateful for fruitful discussions with M. Lyutikov and E. Kravchenko, and thanks D. Gabuzda for her input that helped to improve the paper. We thank the National Radio Astronomy Observatory, a facility of the National Science Foundation operated under cooperative agreement by Associated Universities, Inc.; this research has made use of data from the MOJAVE database that is maintained by the MOJAVE team (Lister et al. 2009) and IRAM, which is supported by INSU/CNRS (France), MPG (Germany) and IGN (Spain). This work has benefited from research funding from the European Community's Seventh Framework Programme. The Submillimeter Array is a joint project between the Smithsonian Astrophysical Observatory and the Academia Sinica Institute of Astronomy and Astrophysics and is funded by the Smithsonian Institution and the Academia Sinica. We also thank J. E. Davis for the development of the slxfig module that has been used to prepare the figures in this work. We made use of ISIS functions provided by ECAP/Remeis observatory and MIT (http://www.sternwarte.uni-erlangen.de/isis/) as well as the NASA/IPAC Extragalactic Database (NED), which is operated by the Jet Propulsion Laboratory, California Institute of Technology, under contract with the National Aeronautics and Space Administration. M.P. acknowledges financial support from the Spanish Ministerio de Economia, Industria y Competitividad (grants AYA2013-40979-P, and AYA2013-48226- C3-2-P) and from the local Valencian Government (Generalitat Valenciana, grant Prometeo-11/2014/069). I.A. acknowledges support by a Ramon y Cajal grant of the Ministerio de Economia y Competitividad (MINECO) of Spain. A.B.P. and Y.Y.K. acknowledge partial support by the Russian Foundation for Basic Research (grant 17-02-00197), by the government of the Russian Federation (agreement 05.Y09.21.0018), and by the Alexander von Humboldt Foundation. E.R. acknowledges partial support by the Spanish MINECO project AYA2012-38491-C02-01 and by the Generalitat Valenciana project PROMETEOII/2014/057. T.S. was funded by the Academy of Finland projects 274477 and 284495. The research at the IAA-CSIC was supported in part by the MINECO through grants AYA2016-80889-P, AYA2013-40825-P, and AYA2010-14844, and by the regional government of Andalucia through grant P09-FQM-4784.

WOS: 000482433800011 ; PubMed ID: 30467691 ; Purpose The aim of the current study was to further investigate the concept of previously reported high occurrence of comorbidities in obstructive sleep patients (OSA) with insomnia-like symptoms. We hypothesized that this finding at least partly is mediated by nocturnal hypoxia. Moreover, we speculated that the spectrum of the clinical OSA phenotypes differs between European geographical regions. Methods Cohort of the European Sleep Apnea Database (n = 17,325; 29.9% females) was divided into five subcohorts according to geographical region (North, East, South, West, Central) and further into four clinical presentation phenotypes based on daytime symptoms (EDS) and characteristics suggestive of insomnia. Results The insomnia phenotype (alone or together with EDS) dominated in all European regions. Isolated insomnia, however, was less common in the West. Insomnia phenotype was associated with the highest proportion of cardiovascular comorbidity (51.7% in the insomnia vs. 43.9% in the EDS type). Measures of nocturnal hypoxemia were independently associated with cardiovascular comorbidity in phenotypes with insomnia-like symptoms. The burden of comorbidities was high across all geographical regions and clinical phenotypes. Regional differences were clinically relevant for age (48 vs. 54 years), BMI (29 vs. 34 kg/m(2)), and ODI (15 vs. 32/h). Conclusion High prevalence of particularly cardiovascular comorbidity among patients with insomnia-like symptoms was linked to nocturnal hypoxemia. Considerable differences in clinical presentation were found among OSA patients across Europe. Our data underline that physicians should ask their patients with suspected OSA also for insomnia symptoms. It remains to be explored if a reduction of nocturnal hypoxemia predicts the improvement of insomnia symptoms. ; European Union COST action B26; European Respiratory Society (ERS); ResMed Inc.; Philips Respironics Inc. ; The ESADA network has received support from the European Union COST action B26. The European Respiratory Society (ERS) supports the ESADA for the second period as a Clinical Research Collaboration (CRC) (2015-2017 and 2018-2020). Unrestricted seeding grants from ResMed Inc. and Philips Respironics Inc. for establishment of the organization and the database are gratefully acknowledged.

The authors regret that they have to correct the acknowledgement of the above mentioned publication as follows: This article/publication is based upon work from COST Action BM1203 (EU-ROS), supported by COST (European Cooperation in Science and Technology) which is funded by the Horizon 2020 Framework Programme of the European Union. COST (European Cooperation in Science and Technology) is a funding agency for research and innovation networks. Our Actions help connect research initiatives across Europe and enable scientists to grow their ideas by sharing them with their peers. This boosts their research, career and innovation. For further information see www.cost.eu. The authors would like to apologise for any inconvenience caused. ; This article/publication is based upon work from COST Action BM1203 (EU-ROS), supported by COST (European Cooperation in Science and Technology) which is funded by the Horizon 2020 Framework Programme of the European Union. COST (European Cooperation in Science and Technology) is a funding agency for research and innovation networks.