Suchergebnisse

AbstractTapping urban and soundscape heritage in urban forests contributes to the conservation and utility of cultural heritage. However, urban heritage and soundscapes might be damaged by urban renewal and geological changes. Poems describing urban and soundscape heritage have been poorly researched due to the obscurity, fragmentation, and inaccessibility of historical materials. This study explores the tendencies of ancient poets toward poetized locales and soundscapes and investigates the present conservation of cultural heritage. This study uses historical sensing to assess the spatial information and auditory sensations about cultural heritage in poems through manual collation. Most of the sites in the poems are currently distributed in urban green spaces with good greenery conditions. These sites are mostly located in the downtown area (38.1%) and outskirts (38.1%) of Fuzhou and are well-preserved urban heritage sites. Generally, the poets preferred to describe birds chirping and visited sites with high forest coverage, such as mountains. The methodology of this study can provide a reference for other research on urban and soundscape heritage, helping with the excavation of natural culture and historical resource conservation in cities.

Abstract
Resveratrol is an antiaging, antioxidant, and anti-inflammatory natural polyphenolic compound. Growing evidence indicates that resveratrol has potential therapeutic effects for improving aging ovarian function. However, the mechanisms underlying prolonged reproductive longevity remain elusive. We found that resveratrol ameliorates ovarian aging transcriptome, some of which are associated with specific changes in methylome. In addition to known aging transcriptome of oocytes and granulosa cells such as decline in oxidoreductase activity, metabolism and mitochondria function, and elevated DNA damage and apoptosis, actin cytoskeleton are notably downregulated with age, and these defects are mostly rescued by resveratrol. Moreover, the aging-associated hypermethylation of actin cytoskeleton is decreased by resveratrol. In contrast, deletion of Tet2, involved in DNA demethylation, abrogates resveratrol-reprogrammed ovarian aging transcriptome. Consistently, Tet2 deficiency results in additional altered pathways as shown by increased mTOR and Wnt signaling, as well as reduced DNA repair and actin cytoskeleton with mouse age. Moreover, genes associated with oxidoreductase activity and oxidation–reduction process were hypermethylated in Tet2-deficient oocytes from middle-age mice treated with resveratrol, indicating that loss of Tet2 abolishes the antioxidant effect of resveratrol. Taking together, our finding provides a comprehensive landscape of transcriptome and epigenetic changes associated with ovarian aging that can be reprogrammed by resveratrol administration, and suggests that aberrantly increased DNA methylation by Tet2 deficiency promotes additional aging epigenome that cannot be effectively restored to younger state by resveratrol.