Suchergebnisse

The textured surface with superhydrophobic nature was explored for an anti-biofouling template. Hierarchical structures composed of the nano-scale wrinkle covering on micro-scale polymer pillar patterns were fabricated by combining the deposition of a thin coating layer of biocompatible diamond-like carbon (DLC) and the replica molding of poly-(dimethylsiloxane) (PDMS) micro-pillars. The as-prepared surfaces were shown to have extreme hydrophobicity (static contact angle > 160 degrees) owing to low surface energy (24.2 mN/m) and dual-roughness structures of the DLC coating. It was explored that the hierarchical surfaces showed poor adhesion of the Calf Pulmonary Artery Endothelial (CPAE) cells for cultures of 7 days suggesting that the 3-dimensional (3-D) patterned superhydrophobic DLC coating exhibits excellent anti-biofouling properties against non-specific cell adhesion. In particular, the reduced filopodia extension during cell growth was caused by disconnected focal adhesions on the pillar pattern. This limited cell adhesion could prevent undesired growth and proliferation of biological species on the surface of biomedical devices such as stents, implants or even injection syringes. ; This work was supported by Korea Science and Engineering Foundation (KOSEF) grant funded by the Korea government (MOST) (R01-2007-000-20675-0), the Micro Thermal System Research Center of Seoul National University, and the Korea Research Foundation Grant funded by the Korean Government (MOEHRD) (Grant KRF-J03003). This work was supported in part by a grant (06K1501-01610) from the CNMT under the '21st Century Frontier R&D Programs' of MEST of Korea (MWM, KRL).

One of the CNIC's most important goals in these times of recession is to secure and maintain long term financial support. In June 2012, the Ministry for Economic Affairs and the consortium of private companies in the Pro-CNIC Foundation renewed their commitment to the CNIC. This unique public-private joint initiative is allowing our center to maintain the pioneering drive that resulted in our accreditation as a Severo Ochoa's Center of Excellence in 2011, one of only eight institutes to receive this award in its inaugural year. During 2012 the CNIC has been intensively seeking competitive external research funding, presenting more than 34 applications to the 7th European Union Framework Programme and 17 applications to other international agencies (NIH, Leducq Foundation, etc.). The Center also secured financing from the Spanish Company Fina Biotech to study genetic risk markers of restenosis after coronary stent implantation. The continuing support for the CNIC from the public and private sectors is based on the strength of our programs in basic and translational research and our innovative training programs aimed at identifying and supporting talent and cementing long term collaboration between basic researchers and clinicians. [.] ; Sí