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There is widespread agreement that the South has changed dramatically since the end of World War II. Social, demographic, economic, and political changes have altered significantly the region long considered the nation's most distinctive. There is less agreement, however, about the extent to which the forces of nationalization have eroded the major elements of Southern distinctiveness. Although this volume does not purport to settle the debate on Southern political change, it does present a variety of recent evidence that helps put this important debate into perspe

You can't win the presidency without winning the South, or so the saying goes—but what does "winning the South" actually entail? How is the southern electoral landscape distinct? Presidential Elections in the South offers a comprehensive examination of the trends driving election outcomes in the region since 1948. The authors assess the electoral significance of everything from religious conservatism, racial bias, and demographic change to party identification, challenger quality, and nomination rules at the primary level. Each chapter traces the importance of a particular issue over time, then investigates how that issue played out in the 2008 presidential election. Incorporating a thoughtful analysis of overarching themes, the book highlights unique regional dynamics within a broad national context

Frontmatter -- Contents -- Tables and Figures -- Dedications and Acknowledgments -- Contributors -- Foreword -- Gregory Hadley -- Section I Language Education Responds to the Call for Peace -- 1 The Call for Peace in Language Education: This Book's Purpose, Themes and Peace Approach -- 2 Empowering Language Teachers to Be Influential Peacebuilders: Knowledge, Competencies and Activities -- 3 The Nonverbal Channels of Peacebuilding: What Teachers, Trainers and Facilitators Need to Know -- Section II: Applying Peacebuilding for Inner, Interpersonal and Intergroup Peace -- 4 Inner Peace and Emotion Regulation during Oral Production in ESL/EFL Teacher Education -- 5 How Increased Self-regulation, Learner Autonomy and Learner Cooperation Raise Self-esteem and Consequently Inner Peace and Interpersonal Peace: Insights from an Innovative School Context -- 6 Revolutionary Love and Peace in the Construction of an English Teacher's Professional Identity -- Seeking Connection through Difference: Finding the Nexus of Transformative Learning, Peacebuilding and Language Teaching -- Section III: Applying Peacebuilding for Intercultural and International Peace -- 8 Can Foreign Languages Be Taught for Peace at US Government Institutes? -- 9 International Faculty and International Students in Universities: Their Roles in Fostering Peace across Languages and Cultures -- 10 Promoting Peace through Social Justice Pedagogies for Students from Immigrant Muslim Communities: Using Critical Language Awareness in Second Language Classrooms -- Section IV: Applying Peacebuilding through Positive Psychology, Peace Linguistics and Peace Language -- 11 Acting Locally to Integrate Positive Psychology and Peace: Practical Applications for Language Teaching and Learning -- 12 From Hate Speech to Empathy: Lessons for Language Educators and Society -- 13 Applying Peace Linguistics: What Peacebuilders Can Learn from the Languages of Hurt, Hate and Harm -- 14 Exploring Peace Language: Hope, Help and Harmony -- Section V: Moving Further with Peacebuilding -- 15 Peacebuilding through Classroom Activities: Inner, Interpersonal, Intergroup, Intercultural, International and Ecological Peace -- 16 Conclusion: Integrating Peace Concepts, Personal Insights and Future Peace Directions -- Index

Background: About 20% of patients diagnosed with endometrial cancer (EC) are considered high-risk with unfavorable prognosis. In the framework of the European Network for Individualized Treatment in EC (ENITEC), we investigated the presence and phenotypic features of Circulating Tumor Cells (CTC) in high-risk EC patients. Methods: CTC isolation was carried out in peripheral blood samples from 34 patients, ranging from Grade 3 Stage IB to Stage IV carcinomas and recurrences, and 27 healthy controls using two methodologies. Samples were subjected to EpCAM-based immunoisolation using the CELLection™ Epithelial Enrich kit (Invitrogen, Dynal) followed by RTqPCR analysis. The phenotypic determinants of endometrial CTC in terms of pathogenesis, hormone receptor pathways, stem cell markers and epithelial to mesenchymal transition (EMT) drivers were asked. Kruskal-Wallis analysis followed by Dunn's post-test was used for comparisons between groups. Statistical significance was set at p < 0.05. Results: EpCAM-based immunoisolation positively detected CTC in high-risk endometrial cancer patients. CTC characterization indicated a remarkable plasticity phenotype defined by the expression of the EMT markers ETV5, NOTCH1, SNAI1, TGFB1, ZEB1 and ZEB2. In addition, the expression of ALDH and CD44 pointed to an association with stemness, while the expression of CTNNB1, STS, GDF15, RELA, RUNX1, BRAF and PIK3CA suggested potential therapeutic targets. We further recapitulated the EMT phenotype found in endometrial CTC through the up-regulation of ETV5 in an EC cell line, and validated in an animal model of systemic dissemination the propensity of these CTC in the accomplishment of metastasis. Conclusions: Our results associate the presence of CTC with high-risk EC. Gene-expression profiling characterized a CTC-plasticity phenotype with stemness and EMT features. We finally recapitulated this CTC-phenotype by over-expressing ETV5 in the EC cell line Hec1A and demonstrated an advantage in the promotion of metastasis in an in vivo mouse model of CTC dissemination and homing. ; ISCIII PI11/00873; Fundación Asociación Española Contra el Cancer (AECC), Grupos Estables 2011; InveNNta (Innovation in Nanomedicine), co-financed by the European Union (EU) through the Operational Programme for Cross-border Cooperation, Spain-Portugal (POCTEP 2007-2013), European Regional Development Fund (ERDF); Helse Vest, Research Council of Norway, Norwegian Cancer Society and Harald Andersens legat (H.B.S.); L. Alonso-Alconada is recipient of fellowship from the Basque Government (Spain).

This essential party primer includes new chapters on polarization between and within the parties in the aftermath of the 2012 election, demographic changes to America's political parties and the effects of new media and campaign finance laws, and the implications of all these things on future policymaking and electoral prospects moving forward.