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In the past fifteen years, there has been a virtual explosion of anthropological literature arguing that morality should be considered central to human practice. Out of this explosion new and invigorating conversations have emerged between anthropologists and philosophers. Moral Engines: Exploring the Ethical Drives in Human Life includes essays from some of the foremost voices in the anthropology of morality, offering unique interdisciplinary conversations between anthropologists and philosophers about the moral engines of ethical life, addressing the question: What propels humans to act in light of ethical ideals?

This innovative collection examines the transnational movements, effects, and transformations of religion in the contemporary world, offering a fresh perspective on the interrelation between globalization and religion. Transnational Transcendence challenges some widely accepted ideas about this relationship-in particular, that globalization can be understood solely as an economic phenomenon and that its religious manifestations are secondary. The book points out that religion's role remains understudied and undertheorized as an element in debates about globalization, and it raises questions about how and why certain forms of religious practice and intersubjectivity succeed as they cross national and cultural boundaries. Framed by Thomas J. Csordas's introduction, this timely volume both urges further development of a theory of religion and globalization and constitutes an important step toward that theory

Louis Dumont's concept of hierarchy continues to inspire social scientists. Using it as their starting point, the contributors to this volume introduce both fresh empirical material and new theoretical considerations. On the basis of diverse ethnographic contexts in Oceania, Asia, and the Middle East they challenge some current conceptions of hierarchical formations and reassess former debates - of post-colonial and neo-colonial agendas, ideas of "democratization" and "globalization," and expanding market economies - both with regard to new theoretical issues and the new world situation

The U.S. health care system presents American Indian/Alaska Native populations with inequitable challenges that result in some of the worst health outcomes in the country. The literature indicates that increasing the proportion of American Indian/Alaska Native health professionals can improve these health disparities. This study aimed to explore the severe under-representation of American Indians and Alaska Natives in Nebraska's health professions workforce by examining barriers and facilitators in this population's pursuit of health professions careers. We conducted demographic questionnaires and three talking circles with students in reservation and urban settings to better understand their lived experiences of pursuing health professions careers. We analyzed these qualitative data through content analysis and identified eight emergent themes—four barriers and four facilitators. These findings can inform the development of strategies to improve Indigenous education, research, and pathways that promote increased American Indian/Alaska Native representation in health care.

In August 2006, the Australian government approved subsidized trastuzumab therapy for human epidermal growth factor receptor 2 (HER2)-positive early breast cancer, and it was mandated that HER2 testing should be performed using in situ hybridization (ISH) rather than immunohistochemistry (IHC). Here we review results of the first regulated, nationwide program to provide HER2 ISH testing for all newly diagnosed breast cancer patients, with a particular emphasis on cases where IHC and ISH results were discordant. Data from all laboratories participating in the program were collated. Cases with an equivocal ISH test result [by chromogenic ISH (CISH) or silver ISH (SISH)] were tested centrally by fluorescence ISH. Most laboratories also performed HER2 IHC, and 200 cases with discordant IHC and ISH results were selected for further analysis in a central laboratory. A total of 26 laboratories were involved and 53,402 tests were reported. Over a 4-year period the HER2 positivity rate decreased for primary cancers from 23.8 to 14.6 %, but remained relatively constant for samples from metastases. Average ISH reporting times were <5 days for all yearly reporting periods. Test-repeat rates decreased for CISH (8.9–3.6 %) and SISH (13.7–8.4 %). Only 12 of 196 cases remained discordant after retesting in a central laboratory. These findings demonstrate the successful implementation of a regulated, national program that continues to collect data on HER2 status. The results also highlight the differences in IHC interpretation between local laboratories and a central, more experienced, laboratory. This model could be used to establish future biomarker-testing programs in other countries.

Objective: Current research does not provide a clear explanation for why some patients with Parkinson's Disease (PD) develop psychotic symptoms. The 'aberrant salience hypothesis' of psychosis has been influential and proposes that dopaminergic dysregulation leads to inappropriate attribution of salience to irrelevant/non-informative stimuli, facilitating the formation of hallucinations and delusions. The aim of this study is to investigate whether non-motivational salience is altered in PD patients and possibly linked to the development of psychotic symptoms. Methods: We investigated salience processing in 14 PD patients with psychotic symptoms, 23 PD patients without psychotic symptoms and 19 healthy controls. All patients were on dopaminergic medication for their PD. We examined emotional salience using a visual oddball fMRI paradigm that has been used to investigate early stages of schizophrenia spectrum psychosis, controlling for resting cerebral blood flow as assessed with arterial spin labelling fMRI. Results: We found significant differences between patient groups in brain responses to emotional salience. PD patients with psychotic symptoms had enhanced brain responses in the striatum, dopaminergic midbrain, hippocampus and amygdala compared to patients without psychotic symptoms. PD patients with psychotic symptoms showed significant correlations between the levels of dopaminergic drugs they were taking and BOLD signalling, as well as psychotic symptom scores. Conclusion: Our study suggests that enhanced signalling in the striatum, dopaminergic midbrain, the hippocampus and amygdala is associated with the development of psychotic symptoms in PD, in line with that proposed in the 'aberrant salience hypothesis' of psychosis in schizophrenia. ; This study was supported by a MRC Clinician Scientist [G0701911] and an Isaac Newton Trust award to G.K.M., and by the Cambridge NIHR Biomedical Research Centre; and by the European Union's Horizon 2020 to F.K. [754462]. T.W.R. discloses consultancy with Cambridge Cognition, Unilever and Greenfield Bioventures; he receives royalties from Cambridge Cognition, research grants from Shionogi & Co and GlaxoSmithKline, and editorial honoraria from Springer Nature and Elsevier. None of these conflict with the findings reported in this manuscript. None of the other authors report any conflicts of interest. R.A.B. discloses consultancy with Living Cell Technologies; Novo Nordisk; BlueRock Therapeutics; Fujifilm Cellular Dynamics Inc; Aspen Neuroscience and UCB pharma and editorial honoraria from Springer Nature. None of these conflict with the findings reported in this manuscript.

The world we live in is constantly changing. Climate change, transforming gender conceptions, emerging issues of food consumption, novel forms of family life and technological developments are altering central areas of our forms of life. This raises questions of how to cope with and understand the moral changes implicit in such alterations. This volume is the first to address moral change as such. It brings together anthropologists and philosophers to discuss how to study and theorize the change of norms, concepts, emotions, moral frameworks and forms of personhood

peer-reviewed ; The Government of Ireland has positioned design as integral to the innovation landscape. In particular, it encourages innovations from designers that align with six thematic areas identified in the Innovation 2020 report. Those areas are health & medical, information & technology communications (ITC), food, energy, manufacturing & materials and service & business processes. However, research is yet to show the current contribution of design consultancies and their project outcomes categorised within these six priority thematic areas. This paper presents empirical findings on a review of 571 projects advertised on the websites of 26 design consultancies in Ireland. It shows that just under half of the reviewed design projects fall within the thematic project areas. Furthermore, this paper shows the differences between three design disciplines (product design, user-experience design and branding design) and their contribution of projects to each thematic area. The results of this empirical study are relevant and of use to design practitioners, clients and policy makers. For designers, this research identifies opportunities for new business and innovation within the Government of Ireland key thematic areas. For design clients, this research offers opportunities to seek input from relevant design disciplines according to the thematic alignment of their project. For policy makers, this research offers context of the six key thematic areas within the design disciplines in Ireland. Lastly, the results of this research suggest that across the disciplines of product, user-experience and branding design, preferred priority themes are evident.

RATIONALE: A microdeletion at locus 15q13.3 is associated with high incidence rates of psychopathology, including schizophrenia. A mouse model of the 15q13.3 microdeletion syndrome has been generated (Df[h15q13]/+) with translational utility for modelling schizophrenia-like pathology. Among other deficits, schizophrenia is characterised by dysfunctions in prefrontal cortical (PFC) inhibitory circuitry and attention. OBJECTIVES: The objective of this study is to assess PFC-dependent functioning in the Df(h15q13)/+ mouse using electrophysiological, pharmacological, and behavioural assays. METHOD: Experiments 1-2 investigated baseline firing and auditory-evoked responses of PFC interneurons and pyramidal neurons. Experiment 3 measured pyramidal firing in response to intra-PFC GABAA receptor antagonism. Experiments 4-6 assessed PFC-dependent attentional functioning through the touchscreen 5-choice serial reaction time task (5-CSRTT). Experiments 7-12 assessed reversal learning, paired-associate learning, extinction learning, progressive ratio, trial-unique non-match to sample, and object recognition. RESULTS: In experiments 1-3, the Df(h15q13)/+ mouse showed reduced baseline firing rate of fast-spiking interneurons and in the ability of the GABAA receptor antagonist gabazine to increase the firing rate of pyramidal neurons. In assays of auditory-evoked responses, PFC interneurons in the Df(h15q13)/+ mouse had reduced detection amplitudes and increased detection latencies, while pyramidal neurons showed increased detection latencies. In experiments 4-6, the Df(h15q13)/+ mouse showed a stimulus duration-dependent decrease in percent accuracy in the 5-CSRTT. The impairment was insensitive to treatment with the partial α7nAChR agonist EVP-6124. The Df(h15q13)/+ mouse showed no cognitive impairments in experiments 7-12. CONCLUSION: The Df(h15q13)/+ mouse has multiple dysfunctions converging on disrupted PFC processing as measured by several independent assays of inhibitory transmission and attentional function. ; The research leading to these results has received support from the Innovative Medicine Initiative Joint Undertaking under grant agreement n° 115008 of which resources are composed of EFPIA in-kind contribution and financial contribution from the European Union's Seventh Framework Programme (FP7/2007-2013). The Behavioural and Clinical Neuroscience Institute is co-funded by the Medical Research Council and the Wellcome Trust. This study was also supported by the Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM). The authors would like to thank Mercedes Nuñez, Noemí Jurado, Edita Bulovaitė, Sueda Tunçak, Lewis Buss, and Diab Ali for skillful technical assistance. ; This is the final version of the article. It first appeared from Springer via https://doi.org/10.1007/s00213-016-4265-2

Environmental problems, at local scale as well as global scale, are now considered as key issues and scientists are encouraged to be part of the process to address these issues. For the last decades, scholars have been focusing on the study of interactions between social dynamics and ecological processes and produced a set of concepts and scientific discourses aiming at framing the analysis of socio-ecological dynamics and eventually at orienting interventions. Scientific discourses are produced by scholars who belong to different groups (resilience, vulnerability, political ecology, commons, robustness …) which identity go beyond disciplines, methods, frameworks and concepts and include a collective history on the evolution of ideas and research organization. Different research units based in Montpellier (France) have been conducting research on socio-ecological systems (SES) to understand many types of relationships, including those between agriculture and biodiversity, policies and landscapes dynamics, watershed management, ecosystem management and health risk. A project named SETER (Socio-Ecological Theories and Empirical Research) was elaborated aiming at assessing the relevance and the complementarities of theoretical frameworks by applying and testing them on several empirical research case studies developed by the participating research units based in Montpellier. We have confronted different scholars, holding the flags of different schools of thought, to the same concrete issues. The purpose of this assessment was to clarify the respective potential of the different theoretical frameworks and to provide the basis for new conceptualizations of socio-ecological systems dynamics and management. Although some authors call for an integrated framework and some advocate for the diversity of explanations, both agree on the fact that there is a need for clarification for a better scientific debate and better interactions with the managers, stakeholders and interested people. The scientific debate remains obscure ...