The Ethics of Research with Human Subjects: Protecting People, Advancing Science, Promoting Trust

In: International Library of Ethics, Law, and the New Medicine Ser v.74

Abstract

Intro -- Dedication -- Acknowledgements -- Contents -- Abbreviations -- Chapter 1: Introduction -- 1.1 Perinatal HIV Prevention Trials -- 1.2 The SUPPORT Study -- 1.3 Hospital Quality Improvement Research -- 1.4 Henrietta Lacks -- 1.5 The Facebook Study -- 1.6 Overview of This Book -- Chapter 2: Historical Background -- 2.1 Research with Human Subjects Before World War II -- 2.2 Research with Human Subjects During World War II -- 2.3 Research with Human Subjects After World War II -- 2.4 The Belmont Report -- 2.5 The U.S. Federal Regulations -- 2.6 Continuing Scandals and Controversies -- 2.7 Concerns About Integrity in Biomedical Research -- 2.8 Jesse Gelsinger's Death -- 2.9 Concerns About Research on Human Biosamples -- 2.10 Conclusion: Human Research Regulations and Guidelines in Historical Context -- Chapter 3: Moral Theory -- 3.1 What Is a Moral Theory? -- 3.2 Moral Subjectivism and Relativism -- 3.3 Classifying Moral Theories -- 3.4 Divine Command Theory -- 3.5 Virtue Ethics -- 3.6 Natural Law Theory -- 3.7 Utilitarianism -- 3.8 Kantianism -- 3.9 Natural Rights Theories -- 3.10 Pluralistic Theories -- 3.11 Conclusion: Toward a Decision-Making Framework -- Chapter 4: Trust as a Foundation for Research with Human Subjects -- 4.1 What Is Trust? -- 4.2 Trust in Research Involving Research with Human Subjects -- 4.3 Trust as a Foundation for the Ethics of Research with Human Subjects: Some Alternative Views -- 4.4 Trust as a Foundation for the Ethics of Research with Human Subjects: My View -- 4.5 Promoting Trust in Research with Human Subjects -- 4.6 The Relationship Between Moral Principles and Research Regulations and Guidelines -- 4.7 The Role of Trust in Resolving Ethical Dilemmas in Research with Human Subjects -- 4.8 Objections to My View -- 4.9 Conclusion -- Chapter 5: Informed Consent -- 5.1 Trust and Informed Consent