A Rule-Based method to model myocardial fiber orientation for simulating ventricular outflow tract arrhythmias

Abstract

Comunicació presentada a: FIMH 2017 9th International Conference, celebrada a Toronto, Canadà, de l'11 al 13 de juny de 2017. ; Myocardial fiber orientation determines the propagation of electrical waves in the heart and the contraction of cardiac tissue. One common approach for assigning fiber orientation to cardiac anatomi- cal models are Rule-Based Methods (RBM). However, RBM have been developed to assimilate data mostly from the Left Ventricle. In conse- quence, fiber information from RBM does not match with histological data in other areas of the heart, having a negative impact in cardiac simulations beyond the LV. In this work, we present a RBM where fiber orientation is separately modeled in each ventricle following observations from histology. This allows to create detailed fiber orientation in specific regions such as the right ventricle endocardium, the interventricular sep- tum and the outow tracts. Electrophysiological simulations including these anatomical structures were then performed, with patient-specific data of outow tract ventricular arrhythmias (OTVA) cases. A compar- ison between the obtained simulations and electro-anatomical data of these patients confirm the potential for in silico identification of the site of origin in OTVAs before the intervention. ; This work was partially funded by the European Union under the Horizon 2020 Programme for Research, Innovation (grant agreement No. 642676 CardioFunX- ion)