Open Access BASE2017

Circulating and Tissue-resident CD4+ T Cells With Reactivity to Intestinal Microbiota Are Abundant in Healthy Individuals and Function is Altered During Inflammation

Hegazy, Ahmed N; West, Nathaniel R; Stubbington, Michael J. T; Wendt, Emily; Suijker, Kim I. M; Datsi, Angeliki; This, Sebastien; Danne, Camille; Campion, Suzanne; Duncan, Sylvia H; Owens, Benjamin M. J; Uhlig, Holm H; McMichael, Andrew; Oxford IBD Cohort Investigators; Bergthaler, Andreas; Teichmann, Sarah A; Keshav, Satish; Powrie, Fiona

Open Access

Abstract

Grant support: ANH was supported by an EMBO long-term fellowship and a Marie Curiefellowship. NRW was supported by a CRI Irvington Post-doctoral Fellowship. BMJO was supported by an Oxford-UCB Pharma Postdoctoral Fellowship. MJTS and SAT were supported by ERC grant ThSWITCH and ThDEFINE (260507). SC and AM were supported by the Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (grant UM1-AI100645). The Rowett Institute of Nutrition and Health receives financial support from the Scottish Government Rural andEnvironmental Sciences and Analytical Services (SG-RESAS). Foundation Louis Jeantet, Wellcome Trust (Investigator award 095688/Z/11/Z), and ERC (ERC/HN/2013/21) supported FPand this project. HHU is supported by the Crohn's & Colitis Foundation of America (CCFA), The Leona M. and Harry B. Helmsley Charitable Trust. SD receive financial support from the ScottishGovernment Rural and Environmental Sciences and Analytical Services (RESAS). ; Peer reviewed ; Publisher PDF

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