An epigenetic score for BMI based on DNA methylation correlates with poor physical health and major disease in the Lothian Birth Cohort

Abstract

Acknowledgements: The authors thank all LBC study participants and research team members who have contributed, and continue to contribute, to the ongoing LBC study. The LBC1936 is supported by Age UK (Disconnected Mind programme) and the Medical Research Council [MR/M01311/1]. The LBC1921 is supported by the Biotechnology and Biological Sciences Research Council [SR176], the Chief Scientist Office [CZB/4/505; ETM/55] and the Medical Research Council [R42550]. Methylation typing was supported by the Centre for Cognitive Ageing and Cognitive Epidemiology (Pilot Fund award), Age UK, The Wellcome Trust Institutional Strategic Support Fund, The University of Edinburgh, and The University of Queensland. This work was conducted in the Centre for Cognitive Ageing and Cognitive Epidemiology, which is supported by the Medical Research Council and Biotechnology and Biological Sciences Research Council [MR/K026992/1], and which supports Ian Deary. Generation Scotland received core support from the Chief Scientist Office of the Scottish Government Health Directorates [CZD/16/6] and the Scottish Funding Council [HR03006]. Genotyping of the GS:SFHS samples was carried out by the Genetics Core Laboratory at the Wellcome Trust Clinical Research Facility, Edinburgh, Scotland, and was funded by the Medical Research Council UK and the Wellcome Trust (Wellcome Trust Strategic Award "STratifying Resilience and Depression Longitudinally" [(STRADL) 104036/Z/14/Z]) ; Peer reviewed ; Publisher PDF