Suchergebnisse

Copia digital. Valladolid : Junta de Castilla y León. Consejería de Cultura y Turismo, 2009-2010 ; Sign.: A-E4, F2 ; Port. con orla tip.

Maqui (Aristotelia Chilensis) berry features a unique profile of anthocyanidins that includes high amounts of delphinidin-3-O-sambubioside-5-O-glucoside and delphinidin-3-O-sambubioside and has shown positive effects on fasting glucose and insulin levels in humans and murine models of type 2 diabetes and obesity. The molecular mechanisms underlying the impact of maqui on the onset and development of the obese phenotype and insulin resistance was investigated in high fat diet-induced obese mice supplemented with a lyophilized maqui berry. Maqui-dietary supplemented animals showed better insulin response and decreased weight gain but also a differential expression of genes involved in de novo lipogenesis, fatty acid oxidation, multilocular lipid droplet formation and thermogenesis in subcutaneous white adipose tissue (scWAT). These changes correlated with an increased expression of the carbohydrate response element binding protein b (Chrebpb), the sterol regulatory binding protein 1c (Srebp1c) and Cellular repressor of adenovirus early region 1A–stimulated genes 1 (Creg1) and an improvement in the fibroblast growth factor 21 (FGF21) signaling. Our evidence suggests that maqui dietary supplementation activates the induction of fuel storage and thermogenesis characteristic of a brown-like phenotype in scWAT and counteracts the unhealthy metabolic impact of an HFD. This induction constitutes a putative strategy to prevent/treat diet-induced obesity and its associated comorbidities. ; This study was supported by the Ministerio de Economía y Competitividad (grants AGL2017-82417-R to PFM and DH and AGL2016-75329-R to RML-R), by the Generalitat (grants 2017SGR683 and 2017SGR196), by the Associació Catalana de la Diabetis to JR (grant 600004—Ajut ACD a la recerca en diabetis 2017), Instituto de Salud Carlos III, ISCIII from the Ministerio de Ciencia, Innovación y Universidades (CIBEROBN—AEI/FEDER, UE). VS was supported by Conicyt's fellowship from the Government of Chile. UM-G was supported by Conacyt's fellowship from the Government of México. JMC was supported by BEC.AR fellowship from Ministerio de Educación, Cultura, Ciencia y Tecnología, Argentina. The APC was funded by the University of Barcelona.