TY  - GEN
TI  - The early-life exposome and epigenetic age acceleration in children
AU  - Prado Bert, Paula de
AU  - Ruiz-Arenas, Carlos
AU  - Vives-Usano, Marta
AU  - Andrusaityte, Sandra
AU  - Cadiou, Solène
AU  - Carracedo Álvarez, Ángel María
AU  - Casas, Maribel
AU  - Chatzi, Leda
AU  - Dadvand, Payam
AU  - González Ruiz, Juan Ramon
AU  - Grazuleviciene, Regina
AU  - Gutzkow, Kristine Bjerve
AU  - Haug, Line Småstuen
AU  - Hernandez Ferrer, Carles
AU  - Keun, Hector C
AU  - Lepeule, Johanna
AU  - Maitre, Léa
AU  - McEachan, Rosemary
AU  - Nieuwenhuijsen, Mark J
AU  - Pelegrí, Dolors
AU  - Robinson, Oliver
AU  - Slama, Rémy
AU  - Vafeiadi, Marina
AU  - Sunyer, Jordi
AU  - Vrijheid, Martine
AU  - Bustamante, Mariona
PB  - Elsevier
LA  - eng
KW  - Aging
KW  - Epigenetic age acceleration
KW  - Pregnancy
KW  - Childhood
KW  - Environmental exposures
AB  - The early-life exposome influences future health and accelerated biological aging has been proposed as one of the underlying biological mechanisms. We investigated the association between more than 100 exposures assessed during pregnancy and in childhood (including indoor and outdoor air pollutants, built environment, green environments, tobacco smoking, lifestyle exposures, and biomarkers of chemical pollutants), and epigenetic age acceleration in 1,173 children aged 7 years old from the Human Early-Life Exposome project. Age acceleration was calculated based on Horvath's Skin and Blood clock using child blood DNA methylation measured by Infinium HumanMethylation450 BeadChips. We performed an exposure-wide association study between prenatal and childhood exposome and age acceleration. Maternal tobacco smoking during pregnancy was nominally associated with increased age acceleration. For childhood exposures, indoor particulate matter absorbance (PMabs) and parental smoking were nominally associated with an increase in age acceleration. Exposure to the organic pesticide dimethyl dithiophosphate and the persistent pollutant polychlorinated biphenyl-138 (inversely associated with child body mass index) were protective for age acceleration. None of the associations remained significant after multiple-testing correction. Pregnancy and childhood exposure to tobacco smoke and childhood exposure to indoor PMabs may accelerate epigenetic aging from an early age ; The study received funding from the European Community's Seventh Framework Programme (FP7/2007-206) (grant agreement no 308333) (HELIX project), the H2020-EU.3.1.2. - Preventing Disease Programme (grant agreement no 874583) (ATHLETE project), and from the European Union's Horizon 2020 research and innovation programme (grant Agreement number: 733206) (Early Life stressors and Lifecycle Health (LIFECYCLE)). BiB received funding from the Welcome Trust (WT101597MA), from the UK Medical Research Council (MRC) and Economic and Social Science Research Council (ESRC) ...
UR  - http://hdl.handle.net/10347/26749
DO  - 10.1016/j.envint.2021.106683
UR  - https://www.pollux-fid.de/r/base-ftunivsantcomp:oai:minerva.usc.es:10347/26749
H1  - Pollux (Fachinformationsdienst Politikwissenschaft)
ER  -