TY  - GEN
TI  - Plasma methionine metabolic profile is associated with longevity in mammals
AU  - Mota Martorell, Natàlia
AU  - Jové Font, Mariona
AU  - Berdún Hernández, Rebeca
AU  - Pamplona Gras, Reinald
PY  - 2022
PB  - Nature Research
LA  - eng
AB  - Methionine metabolism arises as a key target to elucidate the molecular adaptations underlying animal longevity due to the negative association between longevity and methionine content. The present study follows a comparative approach to analyse plasma methionine metabolic profile using a LC-MS/MS platform from 11 mammalian species with a longevity ranging from 3.5 to 120 years. Our findings demonstrate the existence of a species-specific plasma profile for methionine metabolism associated with longevity characterised by: i) reduced methionine, cystathionine and choline; ii) increased non-polar amino acids; iii) reduced succinate and malate; and iv) increased carnitine. Our results support the existence of plasma longevity features that might respond to an optimised energetic metabolism and intracellular structures found in long-lived species. ; This work was supported by the Spanish Ministry of Science, Innovation and Universities (RTI2018-099200-B-I00), and the Generalitat of Catalonia (Agency for Management of University and Research Grants (2017SGR696) and Department of Health (SLT002/16/00250)) to R.P. This study has been co-financed by FEDER funds from the European Union ("A way to build Europe"). IRBLleida is a CERCA Programme/Generalitat of Catalonia. M.J. is a 'Serra Hunter' Fellow. N.M.M. received a predoctoral fellowship from the Generalitat of Catalonia (AGAUR, ref 2018FI_B2_00104).
UR  - http://hdl.handle.net/10459.1/72754
DO  - 10.1038/s42003-021-02254-3
UR  - https://www.pollux-fid.de/r/base-ftunivlleida:oai:repositori.udl.cat:10459.1/72754
H1  - Pollux (Fachinformationsdienst Politikwissenschaft)
ER  -