TY  - GEN
TI  - Biomarkers of Low-Level Environmental Exposure to Benzene and Oxidative DNA Damage in Primary School Children in Sardinia, Italy
AU  - Pilia, Ilaria
AU  - Campagna, Marcello
AU  - Marcias, Gabriele
AU  - Fabbri, Daniele
AU  - Meloni, Federico
AU  - Spatari, Giovanna
AU  - Cottica, Danilo
AU  - Cocheo, Claudio
AU  - Grignani, Elena
AU  - De-Giorgio, Fabio
AU  - Cocco, Pierluigi
AU  - d'Aloja, Ernesto
PY  - 2021
PB  - MDPI
LA  - eng
KW  - Article
AB  - Background: The main anthropic sources of exposure to airborne benzene include vehicular traffic, cigarette smoke, and industrial emissions. Methods: To detect early genotoxic effects of environmental exposure to benzene, we monitored environmental, personal, and indoor airborne benzene in children living in an urban area and an area near a petrochemical plant. We also used urinary benzene and S-phenylmercapturic acid (S-PMA) as biomarkers of benzene exposure and urinary 8-hydroxydeoxyguanosine (8-OHdG) as a biomarker of early genotoxic effects. Results: Although always below the European Union limit of 5 μg/m(3), airborne benzene levels were more elevated in the indoor, outdoor, and personal samples from the industrial surroundings compared to the urban area (p = 0.026, p = 0.005, and p = 0.001, respectively). Children living in the surroundings of the petrochemical plant had urinary benzene values significantly higher than those from the urban area in both the morning and evening samples (p = 0.01 and p = 0.02, respectively). Results of multiple regression modelling showed that age was a significant predictor of 8-OHdG excretion, independent of the sampling hour. Moreover, at the low exposure level experienced by the children participating in this study, neither personal or indoor airborne benzene level, nor personal monitoring data, affected 8-OHdG excretion. Conclusions: Our results suggest the importance of biological monitoring of low-level environmental exposure and its relation to risk of genotoxic effects among children.
UR  - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8123794/
DO  - 10.3390/ijerph18094644
UR  - https://www.pollux-fid.de/r/base-ftpubmed:oai:pubmedcentral.nih.gov:8123794
H1  - Pollux (Fachinformationsdienst Politikwissenschaft)
ER  -